Whole genome resequencing of black Angus and Holstein cattle for SNP and CNV discovery.

ABSTRACT:

Background

One of the goals of livestock genomics research is to identify the genetic differences responsible for variation in phenotypic traits, particularly those of economic importance. Characterizing the genetic variation in livestock species is an important step towards linking genes or genomic regions with phenotypes. The completion of the bovine genome sequence and recent advances in DNA sequencing technology allow for in-depth characterization of the genetic variations present in cattle. Here we describe the whole-genome resequencing of two Bos taurus bulls from distinct breeds for the purpose of identifying and annotating novel forms of genetic variation in cattle.

Results

The genomes of a Black Angus bull and a Holstein bull were sequenced to 22-fold and 19-fold co

SUBMITTER: Stothard P 

PROVIDER: S-EPMC3229636 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature