Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.

ABSTRACT:

Purpose

Human cell lines are useful for studying cancer biology and preclinically modeling cancer therapy, but can be misidentified and cross-contamination is unfortunately common. The purpose of this study was to develop a panel of validated head and neck cell lines representing the spectrum of tissue sites and histologies that could be used for studying the molecular, genetic, and phenotypic diversity of head and neck cancer.

Methods

A panel of 122 clinically and phenotypically diverse head and neck cell lines from head and neck squamous cell carcinoma, thyroid cancer, cutaneous squamous cell carcinoma, adenoid cystic carcinoma, oral leukoplakia, immortalized primary keratinocytes, and normal epithelium was assembled from the collections of several individuals and institut

SUBMITTER: Zhao M 

PROVIDER: S-EPMC3229662 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature