Air pollution, obesity, genes and cellular adhesion molecules.

ABSTRACT:

Objectives

Particulate matter has been associated with acute cardiovascular outcomes, but our understanding of the mechanism is incomplete. We examined the association between particulate matter and cell adhesion molecules. We also investigated the modifying effect of genotype and phenotype variation to gain insight into the relevant biological pathways for this association.

Methods

We used mixed regression models to examine the association of PM(2.5) (particulate matter < or = 2.5 microm in diameter) and black carbon with serum concentrations of soluble intercellular adhesion molecule (sICAM-1) and soluble vascular cell adhesion molecule (sVCAM-1), markers of endothelial function and inflammation, in a longitudinal study of 809 participants in the Normative Ageing Study (18

SUBMITTER: Madrigano J 

PROVIDER: S-EPMC3229824 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature