Peroxisome proliferator-activated receptor γ is a target for halogenated analogs of bisphenol A.

ABSTRACT:

Background

The occurrence of halogenated analogs of the xenoestrogen bisphenol A (BPA) has been recently demonstrated both in environmental and human samples. These analogs include brominated [e.g., tetrabromobisphenol A (TBBPA)] and chlorinated [e.g., tetrachlorobisphenol A (TCBPA)] bisphenols, which are both flame retardants. Because of their structural homology with BPA, such chemicals are candidate endocrine disruptors. However, their possible target(s) within the nuclear hormone receptor superfamily has remained unknown.

Objectives

We investigated whether BPA and its halogenated analogs could be ligands of estrogen receptors (ERs) and peroxisome proliferator-activated receptors (PPARs) and act as endocrine-disrupting chemicals.

Methods

We studied the activity of

SUBMITTER: Riu A 

PROVIDER: S-EPMC3230400 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature