Enhanced antitumor activity of low-dose continuous administration schedules of topotecan in prostate cancer.

ABSTRACT:

Purpose

The objective of this study was to determine the antitumor effects of alternate dosing schedules of topotecan in prostate cancer.

Results

A concentration-dependent increase in cytotoxicity was observed in PC-3 and LNCaP cells after topotecan treatment using conventional and metronomic protocols. A significant increase in potency (2.4-18 fold, after 72 hr) was observed following metronomic dosing compared to conventional dosing administration in both cell lines. Metronomic dosing also increased the percentage of PC-3 cells in the G2/M, compared to control, but did not alter LNCaP cell cycle distribution. Metronomic dosing increased p21 protein expression in LNCaP and PC-3 cells compared to conventional dosing. The observed in vitro activity was confirmed using an in v

SUBMITTER: Aljuffali IA 

PROVIDER: S-EPMC3230472 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature