Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study.

ABSTRACT:

Objective

To examine the relation of midlife raised blood pressure and serum cholesterol concentrations to Alzheimer's disease in later life.

Design

Prospective, population based study.

Setting

Populations of Kuopio and Joensuu, eastern Finland.

Participants

Participants were derived from random, population based samples previously studied in a survey carried out in 1972, 1977, 1982, or 1987. After an average of 21 years' follow up, a total of 1449 (73%) participants aged 65-79 took part in the re-examination in 1998.

Main outcome measures

Midlife blood pressure and cholesterol concentrations and development of Alzheimer's disease in later life.

Results

People with raised systolic blood pressure (>/=160 mm Hg) or high serum cholesterol concentrati

SUBMITTER: Kivipelto M 

PROVIDER: S-EPMC32306 | biostudies-literature | 2001 Jun

REPOSITORIES: biostudies-literature