Demyelination and remyelination in anatomically distinct regions of the corpus callosum following cuprizone intoxication.

ABSTRACT: Multiple sclerosis is a chronic demyelinating disease of the central nervous system. Spontaneous remyelination during early disease stages is thought to preserve and partially restore function. However, this process ceases in later stages despite the presence of pre-oligodendrocytes. Cuprizone-induced demyelination is a useful model with which to study the remyelination process. Previous studies have demonstrated heterogeneities in demyelination in individual animals. Here we investigated regional differences in demyelination and remyelination within the corpus callosum. C57BL/6 mice were fed 0.2% cuprizone for 5 weeks to induce demyelination. Remyelination was examined 2-5 weeks after cuprizone withdrawal. Immunohistochemistry and electron microscopy were used to quantify regional differe

SUBMITTER: Steelman AJ 

PROVIDER: S-EPMC3230728 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature