Association study of candidate gene polymorphisms and obesity in a young Mexican-American population from South Texas.

ABSTRACT:

Background and aims

Obesity is increasingly a health problem and a risk factor for diabetes in young Mexican-American populations. Genetic association studies in older, mostly non-Hispanic populations have reported that polymorphisms in the candidate genes HSD11B1, CRP, ADIPOQ, PPARG, ANKK1, ABCC8 and SERPINF1 are associated with obesity or diabetes. We analyzed the polymorphisms rs846910, rs1205, rs1501299, rs1801282, rs1800497, rs757110 and rs1136287 in these candidate genes, for association with obesity and metabolic traits in a young Mexican-American population from south Texas.

Methods

Genotyping of the seven common SNPs were performed by allelic discrimination assays in 448 unrelated Mexican Americans (median age = 16 years) from south Texas. χ(2) tests and regression

SUBMITTER: Duran-Gonzalez J 

PROVIDER: S-EPMC3230750 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature