Characteristics and molecular basis of celecoxib modulation on K(v)7 potassium channels.

ABSTRACT:

Background and purpose

Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor used for the treatment of pain and inflammation. Emerging and accumulating evidence suggests that celecoxib can affect cellular targets other than COX, such as ion channels. In this study, we characterized the effects of celecoxib on K(v)7 K(+) channels and compared its effects with the well-established K(v)7 channel opener retigabine.

Experimental approach

A perforated whole-cell patch technique was used to record K(v)7currents expressed in HEK 293 cells and M-type currents from rat superior cervical ganglion neurons.

Key results

Celecoxib enhanced K(v)7.2-7.4, K(v)7.2/7.3 and K(v)7.3/7.5 currents but inhibited K(v)7.1 and K(v)7.1/KCNE1 currents and these effects were concentration dep

SUBMITTER: Du XN 

PROVIDER: S-EPMC3230818 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature