The (CTG)n polymorphism in the NOTCH4 gene is not associated with schizophrenia in Japanese individuals.

ABSTRACT:

Background

The human NOTCH4 gene is a candidate gene for schizophrenia due to its chromosomal location and neurobiological roles. In a British linkage study, NOTCH4 gene polymorphisms were highly associated with schizophrenia. In a Japanese case-control association study, however, these polymorphisms did not show significant associations with schizophrenia. We conducted a case-control study with Japanese subjects to explore an association between the triplet repeat polymorphism in the NOTCH4 gene and schizophrenia, including subtypes of schizophrenia, longitudinal disease course characteristics, and a positive family history for psychoses.

Methods

We examined the (CTG)n repeat polymorphism in the NOTCH4 gene among 100 healthy Japanese individuals and 102 patients with schizo

SUBMITTER: Imai K 

PROVIDER: S-EPMC32311 | biostudies-literature | 2001

REPOSITORIES: biostudies-literature