Biomarkers for drug-induced renal damage and nephrotoxicity-an overview for applied toxicology.

ABSTRACT: The detection of acute kidney injury (AKI) and the monitoring of chronic kidney disease (CKD) is becoming more important in industrialized countries. Because of the direct relation of kidney damage to the increasing age of the population, as well as the connection to other diseases like diabetes mellitus and congestive heart failure, renal diseases/failure has increased in the last decades. In addition, drug-induced kidney injury, especially of patients in intensive care units, is very often a cause of AKI. The need for diagnostic tools to identify drug-induced nephrotoxicity has been emphasized by the ICH-regulated agencies. This has lead to multiple national and international projects focusing on the identification of novel biomarkers to enhance drug development. Several parameters relat

SUBMITTER: Fuchs TC 

PROVIDER: S-EPMC3231866 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature