DENSE: efficient and prior knowledge-driven discovery of phenotype-associated protein functional modules.

ABSTRACT:

Background

Identifying cellular subsystems that are involved in the expression of a target phenotype has been a very active research area for the past several years. In this paper, cellular subsystem refers to a group of genes (or proteins) that interact and carry out a common function in the cell. Most studies identify genes associated with a phenotype on the basis of some statistical bias, others have extended these statistical methods to analyze functional modules and biological pathways for phenotype-relatedness. However, a biologist might often have a specific question in mind while performing such analysis and most of the resulting subsystems obtained by the existing methods might be largely irrelevant to the question in hand. Arguably, it would be valuable to incorporate bio

SUBMITTER: Hendrix W 

PROVIDER: S-EPMC3231954 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature