The effect of weight loss and exercise training on flow-mediated dilatation in coronary heart disease: a randomized trial.

ABSTRACT:

Background

More than 80% of patients entering cardiac rehabilitation are overweight, with a high prevalence of associated insulin resistance, diabetes, hypertension, hyperlipidemia, and a prothrombotic state. Because each of these characteristics is associated with abnormalities of endothelial-dependent flow-mediated dilatation (FMD), a predictor of long-term prognosis in patients with coronary heart disease (CHD), we assessed the effect of exercise training and weight reduction on FMD in overweight patients with CHD.

Methods

All patients (N = 38) participated in behavioral weight loss while taking their usual preventive medications. Subjects were randomized to one of two exercise protocols, which differed by caloric expenditure. The primary outcome was extent (%) of brachia

SUBMITTER: Ades PA 

PROVIDER: S-EPMC3231959 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature