Inferring pleiotropy by network analysis: linked diseases in the human PPI network.

ABSTRACT:

Background

Earlier, we identified proteins connecting different disease proteins in the human protein-protein interaction network and quantified their mediator role. An analysis of the networks of these mediators shows that proteins connecting heart disease and diabetes largely overlap with the ones connecting heart disease and obesity.

Results

We quantified their overlap, and based on the identified topological patterns, we inferred the structural disease-relatedness of several proteins. Literature data provide a functional look of them, well supporting our findings. For example, the inferred structurally important role of the PDZ domain-containing protein GIPC1 in diabetes is supported despite the lack of this information in the Online Mendelian Inheritance in Man database

SUBMITTER: Nguyen TP 

PROVIDER: S-EPMC3231966 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature