Acute effects of remote ischemic preconditioning on cutaneous microcirculation--a controlled prospective cohort study.

ABSTRACT:

Background

Therapeutic strategies aiming to reduce ischemia/reperfusion injury by conditioning tissue tolerance against ischemia appear attractive not only from a scientific perspective, but also in clinics. Although previous studies indicate that remote ischemic intermittent preconditioning (RIPC) is a systemic phenomenon, only a few studies have focused on the elucidation of its mechanisms of action especially in the clinical setting. Therefore, the aim of this study is to evaluate the acute microcirculatory effects of remote ischemic preconditioning on a distinct cutaneous location at the lower extremity which is typically used as a harvesting site for free flap reconstructive surgery in a human in-vivo setting.

Methods

Microcirculatory data of 27 healthy subjects (25 mal

SUBMITTER: Kraemer R 

PROVIDER: S-EPMC3231986 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature