Homing and reparative effect of intra-articular injection of autologus mesenchymal stem cells in osteoarthritic animal model.

ABSTRACT:

Background

This work aimed to study the homing evidence and the reparative effect of mesenchymal stem cells (MSCs) in the healing process of induced osteoarthritis in experimental animal model (donkeys).

Methods

Twenty-seven donkeys were equally divided into 3 groups based on the observation period after induction of arthritis (3, 6 and 9 weeks) to achieve different degrees of osteoarthritis. Each group was subdivided into three subgroups of three animals each based on the follow-up period (1, 2 and 6 months) after treatment. The induction was done through intra-articular (IA) injection of 2 ml of Amphotericin-B in both carpal joints. MSCs were harvested in a separate procedure, labeled with green fluorescent protein (GFP) using monster GFP vector and suspended in hyaluronic

SUBMITTER: Mokbel AN 

PROVIDER: S-EPMC3232438 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature