Human immunodeficiency virus type 1 endocytic trafficking through macrophage bridging conduits facilitates spread of infection.

ABSTRACT: Bridging conduits (BC) sustain communication and homeostasis between distant tethered cells. These are also exploited commonly for direct cell-to-cell transfer of microbial agents. Conduits efficiently spread infection, effectively, at speeds faster than fluid phase exchange while shielding the microbe against otherwise effective humoral immunity. Our laboratory has sought to uncover the mechanism(s) for these events for human immunodeficiency virus type one (HIV-1) infection. Indeed, in our prior works HIV-1 Env and Gag antigen and fluorescent virus tracking were shown sequestered into endoplasmic reticulum-Golgi organelles but the outcomes for spreading viral infection remained poorly defined. Herein, we show that HIV-1 specifically traffics through endocytic compartments contained withi

SUBMITTER: Kadiu I 

PROVIDER: S-EPMC3232570 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature