The roles of IL-6, IL-10, and IL-1RA in obesity and insulin resistance in African-Americans.

ABSTRACT:

Objective

The aim of the study was to investigate the associations between IL-1 receptor antagonist (IL-1RA), IL-6, IL-10, measures of obesity, and insulin resistance in African-Americans.

Research design and methods

Nondiabetic participants (n = 1025) of the Howard University Family Study were investigated for associations between serum IL (IL-1RA, IL-6, IL-10), measures of obesity, and insulin resistance, with adjustment for age and sex. Measures of obesity included body mass index, waist circumference, hip circumference, waist-to-hip ratio, and percent fat mass. Insulin resistance was assessed using the homeostasis model assessment of insulin resistance (HOMA-IR). Data were analyzed with R statistical software using linear regression and likelihood ratio tests.

Results

SUBMITTER: Charles BA 

PROVIDER: S-EPMC3232609 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature