Circulating adiponectin is inversely associated with risk of thyroid cancer: in vivo and in vitro studies.

ABSTRACT:

Context

Circulating adiponectin has been inversely associated with risk for several malignancies. Its association with thyroid cancer has not yet been evaluated.

Objective/methods

We measured circulating adiponectin levels in 175 thyroid carcinoma patients and 107 controls. We also examined the expression of adiponectin receptors (AdipoR1 and AdipoR2) using immunohistochemistry in 82 thyroid carcinoma tissues and using RT-qPCR in 40 human thyroid carcinoma tissues (32 papillary, six follicular/Hurthle, one anaplastic, one medullary), four normal human thyroid tissue specimens, and the BHP7 and SW579 thyroid cancer cell lines. We then utilized these thyroid cancer cell lines to investigate whether adiponectin could directly regulate cell cycle or apoptosis.

Results

Thy

SUBMITTER: Mitsiades N 

PROVIDER: S-EPMC3232611 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature