The effects of kisspeptin-10 on reproductive hormone release show sexual dimorphism in humans.

ABSTRACT:

Background

Kisspeptin peptides are critical in human reproductive physiology and are potential therapies for infertility. Kisspeptin-10 stimulates gonadotropin release in both male and female rodents. However, few studies have investigated the effects of kisspeptin-10 on gonadotropin release in humans, and none have investigated the effect in women. If kisspeptin is to be useful for treating reproductive disease, its effects in both men and women must be established.

Aim

To compare the effects of kisspeptin-10 administration on reproductive hormone release in healthy men and women.

Methods

Intravenous bolus kisspeptin-10 was administered to men and women (n = 4-5 per group). Subcutaneous bolus and i.v. infusion of kisspeptin-10 was also administered to female women (n

SUBMITTER: Jayasena CN 

PROVIDER: S-EPMC3232613 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature