Short-term energy deprivation alters activin a and follistatin but not inhibin B levels of lean healthy women in a leptin-independent manner.

ABSTRACT:

Context

Leptin is a potent modulator of the hypothalamic-pituitary-gonadal axis mediating the effect of energy deprivation on several hypothalamic-pituitary-peripheral axes. Activin A, inhibin B, and follistatin (FST) also regulate the hypothalamic-pituitary-gonadal axis in humans. It remains unknown whether energy deprivation affects these hormone levels in a leptin-dependent or -independent manner.

Objective

We investigated 1) day-night variability patterns of activin, inhibin, and FST in the fed state, 2) whether their levels are affected by fasting, and 3) whether such an effect is mediated by leptin in physiological replacement or pharmacological doses.

Design

We conducted two studies in healthy, eumenorrheic females, each comprising three separate admissions. In

SUBMITTER: Moragianni VA 

PROVIDER: S-EPMC3232616 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature