Hereditary pituitary hyperplasia with infantile gigantism.

ABSTRACT:

Context

We report hereditary pituitary hyperplasia.

Objective

The objective of the study was to describe the results of the clinical and laboratory analysis of this rare instance of hereditary pituitary hyperplasia.

Design

The study is a retrospective analysis of three cases from one family.

Setting

The study was conducted at the National Institutes of Health, a tertiary referral center.

Patients

A mother and both her sons had very early-onset gigantism associated with high levels of serum GH and prolactin.

Interventions

The condition was treated by total hypophysectomy.

Main outcome measure(s)

We performed clinical, pathological, and molecular evaluations, including evaluation basal and provocative endocrine testing, neuroradiological asse

SUBMITTER: Glasker S 

PROVIDER: S-EPMC3232621 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature