Polymorphisms in the neuropeptide Y gene and the risk of obesity: findings from two prospective cohorts.

ABSTRACT:

Context

Neuropeptide Y (NPY) increases appetite and food intake in animals. Conflicting evidence has been found for the association between polymorphisms of the NPY gene and obesity in humans.

Objective

The objective of the investigation was to study four single-nucleotide polymorphisms (SNPs) in the NPY gene [rs17149106 (G>T), rs16147 (C>T), rs16139 (T>C), rs5574 (C>T)] with body adiposity.

Design

The study design included a candidate gene association study from two cohorts.

Participants

Two thousand seventy-one women from the Nurses' Health Study and 1268 men from the Health Professionals Follow-Up study participated in the study.

Main outcome measures

Weight and height were self-reported at baseline and updated every 2 yr to calculate body mass index

SUBMITTER: Yeung EH 

PROVIDER: S-EPMC3232624 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature