Prolactin as a marker of successful catheterization during IPSS in patients with ACTH-dependent Cushing's syndrome.

ABSTRACT:

Context

Anomalous venous drainage can lead to false-negative inferior petrosal sinus sampling (IPSS) results. Baseline inferior petrosal sinus to peripheral (IPS/P) prolactin ratio higher than 1.8 ipsilateral to the highest ACTH ratio has been proposed to verify successful catheterization. Prolactin-normalized ACTH IPS/P ratios may differentiate Cushing's disease (CD) from ectopic ACTH syndrome (EAS).

Objective

Our objective was to examine the utility of prolactin measurement during IPSS.

Design, setting, and participants

We conducted a retrospective analysis of prolactin levels in basal and CRH-stimulated IPSS samples in ACTH-dependent Cushing's syndrome (2007-2010).

Results

Twenty-five of 29 patients had a pathologically proven diagnosis (17 CD and eight EAS)

SUBMITTER: Sharma ST 

PROVIDER: S-EPMC3232627 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature