Development of a human-murine chimeric immunoglobulin M for use in the serological detection of human alphavirus antibodies.

ABSTRACT: Diagnosis of human alphaviral infections relies on serological techniques, such as the immunoglobulin M antibody capture-enzyme-linked immunosorbent assay (MAC-ELISA). We have humanized the alphavirus broadly cross-reactive murine monoclonal antibody 1A4B-6 to create a reagent capable of replacing human positive sera in the MAC-ELISA for diagnosis of human alphaviral infections.

SUBMITTER: Thibodeaux BA 

PROVIDER: S-EPMC3232697 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature