New role of the disulfide stress effector YjbH in β-lactam susceptibility of Staphylococcus aureus.

ABSTRACT: Staphylococcus aureus is exposed to multiple antimicrobial compounds, including oxidative burst products and antibiotics. The various mechanisms and regulatory pathways governing susceptibility or resistance are complex and only superficially understood. Bacillus subtilis recently has been shown to control disulfide stress responses by the thioredoxin-related YjbH protein, which binds to the transcriptional regulator Spx and controls its degradation via the proteasome-like ClpXP protease. We show that the S. aureus YjbH homolog has a role in susceptibility to the disulfide stress-inducing agent diamide that is similar to that in B. subtilis, and we demonstrate that the four cysteine residues in YjbH are required for this activity. In addition, the inactivation of YjbH led to moderate resis

SUBMITTER: Gohring N 

PROVIDER: S-EPMC3232775 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature