Functional characterization of the RuvB homologs from Mycoplasma pneumoniae and Mycoplasma genitalium.

ABSTRACT: Homologous recombination between repeated DNA elements in the genomes of Mycoplasma species has been hypothesized to be a crucial causal factor in sequence variation of antigenic proteins at the bacterial surface. To investigate this notion, studies were initiated to identify and characterize the proteins that form part of the homologous DNA recombination machinery in Mycoplasma pneumoniae as well as Mycoplasma genitalium. Among the most likely participants of this machinery are homologs of the Holliday junction migration motor protein RuvB. In both M. pneumoniae and M. genitalium, genes have been identified that have the capacity to encode RuvB homologs (MPN536 and MG359, respectively). Here, the characteristics of the MPN536- and MG359-encoded proteins (the RuvB proteins from M. pneumoni

SUBMITTER: Estevao S 

PROVIDER: S-EPMC3232873 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature