Novel probiotic Bifidobacterium longum subsp. infantis CECT 7210 strain active against rotavirus infections.

ABSTRACT: Rotavirus is the leading cause of severe acute gastroenteritis among children worldwide. It is well known that breast-feeding and vaccination afford infants protection. Since breast-feeding has drastically decreased in developed countries, efforts have been focused on the potential use of probiotics as preventive agents. In this study, a novel Bifidobacterium longum subsp. infantis strain was isolated from infant feces and selected, based on its capacity to inhibit in vitro rotavirus Wa replication (up to 36.05% infectious foci reduction) and also to protect cells from virus infection (up to 48.50% infectious foci reduction) in both MA-104 and HT-29 cell lines. Furthermore, studies using a BALB/c mouse model have proved that this strain provides preliminary in vivo protection against rotav

SUBMITTER: Munoz JA 

PROVIDER: S-EPMC3233071 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature