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Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakage.
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ABSTRACT: Objective
To determine the efficacy of pazopanib eye drops in the streptozotocin induced diabetic retinopathy rat model.Methods
A 0.5% w/v pazopanib suspension was prepared in phosphate buffered saline (PBS, pH 7.4) in the presence of 0.5% w/v sodium carboxymethyl cellulose. Brown Norway rats were divided into three groups (n=4) - (1) healthy, (2) diabetic, and (3) diabetic with treatment. The drug suspension was administered twice daily as eye drops to group 3 for 30 days. Efficacy parameters including the number of adherent leukocytes in the retinal vasculature (leukostasis), blood-retinal FITC-dextran leakage, and vitreous-to-plasma protein ratio were measured.Results
Pazopanib suspension in the form of eye drops significantly reduced leukostasis (32%), FITC-dextran leakage (39%), and the vitreous-to-plasma protein ratio (64%) in diabetic animals compared to untreated diabetic group.Conclusion
Pazopanib eye drops can alleviate retinal complications of diabetic retinopathy.
SUBMITTER: Thakur A
PROVIDER: S-EPMC3233473 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Publications
Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakage.
Microvascular research 20110916 3
<h4>Objective</h4>To determine the efficacy of pazopanib eye drops in the streptozotocin induced diabetic retinopathy rat model.<h4>Methods</h4>A 0.5% w/v pazopanib suspension was prepared in phosphate buffered saline (PBS, pH 7.4) in the presence of 0.5% w/v sodium carboxymethyl cellulose. Brown Norway rats were divided into three groups (n=4) - (1) healthy, (2) diabetic, and (3) diabetic with treatment. The drug suspension was administered twice daily as eye drops to group 3 for 30 days. Effic ...[more]