Synaptic proteins are tonotopically graded in postnatal and adult type I and type II spiral ganglion neurons.

ABSTRACT: Inherent in the design of the mammalian auditory system is the precision necessary to transduce complex sounds and transmit the resulting electrical signals to higher neural centers. Unique specializations in the organ of Corti are required to make this conversion, such that mechanical and electrical properties of hair cell receptors are tailored to their specific role in signal coding. Electrophysiological and immunocytochemical characterizations have shown that this principle also applies to neurons of the spiral ganglion, as evidenced by distinctly different firing features and synaptic protein distributions of neurons that innervate high- and low-frequency regions of the cochlea. However, understanding the fine structure of how these properties are distributed along the cochlear partit

SUBMITTER: Flores-Otero J 

PROVIDER: S-EPMC3233875 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature