Pilot randomized trial of donepezil hydrochloride for delirium after hip fracture.

ABSTRACT:

Objectives

To determine whether donepezil hydrochloride can reduce the prevalence and severity of delirium in older adults undergoing hip fracture repair.

Design

Pilot double-masked randomized placebo-controlled trial.

Setting

Large academic medical center.

Participants

Sixteen individuals aged 70 and older with hip fracture.

Intervention

Donepezil 5 mg or placebo was randomly allocated and initiated within 24 hours of surgery, preoperatively or postoperatively. Daily treatment was continued for 30 days or until side effects or the clinical situation required termination.

Measurements

All outcomes were ascertained masked to treatment status. Information on drug tolerability and safety was obtained from the participant, nurse, and medical record. D

SUBMITTER: Marcantonio ER 

PROVIDER: S-EPMC3233977 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature