Information routing driven by background chatter in a signaling network.

ABSTRACT: Living systems are capable of processing multiple sources of information simultaneously. This is true even at the cellular level, where not only coexisting signals stimulate the cell, but also the presence of fluctuating conditions is significant. When information is received by a cell signaling network via one specific input, the existence of other stimuli can provide a background activity -or chatter- that may affect signal transmission through the network and, therefore, the response of the cell. Here we study the modulation of information processing by chatter in the signaling network of a human cell, specifically, in a Boolean model of the signal transduction network of a fibroblast. We observe that the level of external chatter shapes the response of the system to information carryin

SUBMITTER: Domedel-Puig N 

PROVIDER: S-EPMC3234210 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature