Mechanisms establishing TLR4-responsive activation states of inflammatory response genes.

ABSTRACT: Precise control of the innate immune response is required for resistance to microbial infections and maintenance of normal tissue homeostasis. Because this response involves coordinate regulation of hundreds of genes, it provides a powerful biological system to elucidate the molecular strategies that underlie signal- and time-dependent transitions of gene expression. Comprehensive genome-wide analysis of the epigenetic and transcription status of the TLR4-induced transcriptional program in macrophages suggests that Toll-like receptor 4 (TLR4)-dependent activation of nearly all immediate/early- (I/E) and late-response genes results from a sequential process in which signal-independent factors initially establish basal levels of gene expression that are then amplified by signal-dependent tra

SUBMITTER: Escoubet-Lozach L 

PROVIDER: S-EPMC3234212 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature