A systems view of the protein expression process.

ABSTRACT:

Unlabelled

Many biological processes are regulated by changing the concentration and activity of proteins. The presence of a protein at a given subcellular location at a given time with a certain conformation is the result of an apparently sequential process. The rate of protein formation is influenced by chromatin state, and the rates of transcription, translation, and degradation. There is an exquisite control system where each stage of the process is controlled both by seemingly unregulated proteins as well as through feedbacks mediated by RNA and protein products. Here we review the biological facts and mathematical models for each stage of the protein production process. We conclude that advances in experimental techniques leading to a detailed description of the process have

SUBMITTER: Gokhale S 

PROVIDER: S-EPMC3234314 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature