Osteoinductivity of demineralized bone matrix is independent of donor bisphosphonate use.

ABSTRACT:

Background

Demineralized bone matrix is commonly used as a bone graft substitute, either alone or to supplement an osteoconductive material, because of its osteoinductive properties. The aging of the population has led to an increase in the number of prospective donors of demineralized bone matrix who have taken bisphosphonates to prevent osteoclast-mediated bone resorption. The aim of this study was to determine whether oral bisphosphonate usage affects the osteoinductivity of demineralized bone matrix from donors.

Methods

Sex-matched and age-matched pairs of samples were provided by four tissue banks (three or four pairs per bank). Demineralized bone matrix donors without bisphosphonate treatment had a mean age (and standard deviation) of 69.1 ± 2.5 years, and donors with

SUBMITTER: Schwartz Z 

PROVIDER: S-EPMC3234347 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature