Dissecting the genetics of complex inheritance: linkage disequilibrium mapping provides insight into Crohn disease.

ABSTRACT: Family studies for Crohn disease (CD) report extensive linkage on chromosome 16q and pinpoint NOD2 as a possible causative locus. However, linkage is also observed in families that do not bear the most frequent NOD2 causative mutations, but no other signals on 16q have been found so far in published genome-wide association studies. Our aim is to identify this missing genetic contribution. We apply a powerful genetic mapping approach to the Wellcome Trust Case-Control Consortium and the National Institute of Diabetes and Digestive and Kidney Diseases genome-wide association data on CD. This method takes into account the underlying structure of linkage disequilibrium (LD) by using genetic distances from LD maps and provides a location for the causal agent. We find genetic heterogeneity withi

SUBMITTER: Elding H 

PROVIDER: S-EPMC3234369 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature