Natural positive selection and north-south genetic diversity in East Asia.

ABSTRACT: Recent reports have identified a north-south cline in genetic variation in East and South-East Asia, but these studies have not formally explored the basis of these clinical differences. Understanding the origins of these variations may provide valuable insights in tracking down the functional variants in genomic regions identified by genetic association studies. Here we investigate the genetic basis of these differences with genome-wide data from the HapMap, the Human Genome Diversity Project and the Singapore Genome Variation Project. We implemented four bioinformatic measures to discover genomic regions that are considerably differentiated either between two Han Chinese populations in the north and south of China, or across 22 populations in East and South-East Asia. These measures prio

SUBMITTER: Suo C 

PROVIDER: S-EPMC3234507 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature