Comparative genomics of thiol oxidoreductases reveals widespread and essential functions of thiol-based redox control of cellular processes.

ABSTRACT:

Aims

Redox regulation of cellular processes is an important mechanism that operates in organisms from bacteria to mammals. Much of the redox control is provided by thiol oxidoreductases: proteins that employ cysteine residues for redox catalysis. We wanted to identify thiol oxidoreductases on a genome-wide scale and use this information to obtain insights into the general principles of thiol-based redox control.

Results

Thiol oxidoreductases were identified by three independent methods that took advantage of the occurrence of selenocysteine homologs of these proteins and functional linkages among thiol oxidoreductases revealed by comparative genomics. Based on these searches, we describe thioredoxomes, which are sets of thiol oxidoreductases in organisms. Their analyses reve

SUBMITTER: Fomenko DE 

PROVIDER: S-EPMC3234660 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature