Patterns of histone H3 lysine 27 monomethylation and erythroid cell type-specific gene expression.

ABSTRACT: Post-translational histone modifications, acting alone or in a context-dependent manner, influence numerous cellular processes via their regulation of gene expression. Monomethylation of histone H3 lysine 27 (K27me1) is a poorly understood histone modification. Some reports describe depletion of K27Me1 at promoters and transcription start sites (TSS), implying its depletion at TSS is necessary for active transcription, while others have associated enrichment of H3K27me1 at TSS with increased levels of mRNA expression. Tissue- and gene-specific patterns of H3K27me1 enrichment and their correlation with gene expression were determined via chromatin immunoprecipitation on chip microarray (ChIP-chip) and human mRNA expression array analyses. Results from erythroid cells were compared with thos

SUBMITTER: Steiner LA 

PROVIDER: S-EPMC3234769 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature