The effects of cognitive therapy versus 'no intervention' for major depressive disorder.

ABSTRACT:

Background

Major depressive disorder afflicts an estimated 17% of individuals during their lifetimes at tremendous suffering and costs. Cognitive therapy may be an effective treatment option for major depressive disorder, but the effects have only had limited assessment in systematic reviews.

Methods/principal findings

We used The Cochrane systematic review methodology with meta-analyses and trial sequential analyses of randomized trials comparing the effects of cognitive therapy versus 'no intervention' for major depressive disorder. Participants had to be older than 17 years with a primary diagnosis of major depressive disorder to be eligible. Altogether, we included 12 trials randomizing a total of 669 participants. All 12 trials had high risk of bias. Meta-analysis on th

SUBMITTER: Jakobsen JC 

PROVIDER: S-EPMC3235113 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature