Early neural and vascular changes in the adolescent type 1 and type 2 diabetic retina.

ABSTRACT:

Purpose

This cross-sectional study examines the existence and frequency of functional and structural abnormalities in the adolescent Type 1 diabetic retina. We also compare the results with those of adolescents with Type 2 diabetes.

Methods

Thirty-two adolescents with Type 1 diabetes (5.7 ± 3.6 years; mean duration ± SD), 15 with Type 2 diabetes (2.1 ± 1.3 years), and 26 age-matched control subjects were examined. Multifocal electroretinogram responses from 103 retinal regions were recorded. Optical coherence tomography was used to measure retinal thickness. Vascular diameter around the optic nerve was also assessed.

Results

Nine of the 32 (28%) adolescents with Type 1 diabetes and 6 of the 15 (40%) with Type 2 diabetes had significant multifocal electroretinogram imp

SUBMITTER: Bronson-Castain KW 

PROVIDER: S-EPMC3235228 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature