Proteomic analyses of human plasma: Venus versus Mars.

ABSTRACT:

Background

Plasma is vital for the resuscitation of injured patients and to restore necessary procoagulants, especially Factors (F)II, FV, FVII, FX, and FXIII; however, female plasma has been implicated in the majority of transfusion-related acute lung injury (TRALI) cases and male-only plasma transfusion regimens have significantly decreased the incidence of TRALI. Little is known about the human plasma proteome, and no comparisons have been made between male and female plasma; therefore, we hypothesize that there are significant differences between plasma from male and female donors.

Study design and methods

Five units of fresh-frozen plasma each were collected from nulliparous female donors and male donors, and the proteome was analyzed by depleting the 14 most common pro

SUBMITTER: Silliman CC 

PROVIDER: S-EPMC3235251 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature