Maternal influenza infection during pregnancy impacts postnatal brain development in the rhesus monkey.

ABSTRACT:

Background

Maternal infection with influenza and other pathogens during pregnancy has been associated with increased risk for schizophrenia and neurodevelopmental disorders. In rodent studies, maternal inflammatory responses to influenza affect fetal brain development. However, to verify the relevance of these findings to humans, research is needed in a primate species with more advanced prenatal corticogenesis.

Methods

Twelve pregnant rhesus monkeys were infected with influenza, A/Sydney/5/97 (H3N2), 1 month before term (early third trimester) and compared with 7 control pregnancies. Nasal swabs and blood samples confirmed viral shedding and immune activation. Structural magnetic resonance imaging was conducted at 1 year; behavioral development and cortisol reactivity were

SUBMITTER: Short SJ 

PROVIDER: S-EPMC3235476 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature