Neocortical and hippocampal amyloid-β and tau measures associate with dementia in the oldest-old.

ABSTRACT: The emergence of longevity in the modern world has brought a sense of urgency to understanding age-related neurodegenerative diseases such as Alzheimer's disease. Unfortunately, there is a lack of consensus regarding the correlation between the pathological substrates of neurodegeneration and dementia status, particularly in the oldest-old. To better understand the pathological correlates of dementia in the oldest-old, we characterized the topographical spread and severity of amyloid-β, tau, TDP-43 and α-synuclein pathologies in the 90+ Study, a prospective longitudinal population-based study of ageing and dementia. Neuropathological analysis with immunohistochemically labelled sections was carried out blind to clinical diagnosis on the first 108 participants of the 90+ Study who came to a

SUBMITTER: Robinson JL 

PROVIDER: S-EPMC3235569 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature