Highly Enantioselective Asymmetric Darzens Reactions with a Phase Transfer Catalyst.

ABSTRACT: A class of easily accessible and readily tunable chiral phase transfer catalysts based on 6'-OH cinchonium salts was found to efficiently catalyze an unprecedented highly enantioselective Darzens reaction of α-chloro ketones and aldehydes, which directly produces optically active chiral epoxides from readily available carbonyl compounds.

SUBMITTER: Liu Y 

PROVIDER: S-EPMC3235651 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature