Intercepting Wacker intermediates with arenes: C-H functionalization and dearomatization.

ABSTRACT: An intramolecular cyclization cascade reaction has been developed utilizing a high valent palladium intermediate that generates a carbon-carbon and carbon-oxygen bond in a single transformation. This method provides rapid access to highly functionalized tricyclic scaffolds, including spirocyclic cyclohexadienones. Good yields and mild conditions are reported with high tolerance toward oxygen and water.

SUBMITTER: Matsuura BS 

PROVIDER: S-EPMC3235802 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature