Novel genetic reassortants in H9N2 influenza A viruses and their diverse pathogenicity to mice.

ABSTRACT:

Background

H9N2 influenza A viruses have undergone extensive reassortments in different host species, and could lead to the epidemics or pandemics with the potential emergence of novel viruses.

Methods

To understand the genetic and pathogenic features of early and current circulating H9N2 viruses, 15 representative H9N2 viruses isolated from diseased chickens in northern China between 1998 and 2010 were characterized and compared with all Chinese H9N2 viruses available in the NCBI database. Then, the representative viruses of different genotypes were selected to study the pathogenicity in mice with the aim to investigate the adaptation and the potential pathogenicity of the novel H9N2 reassortants to mammals.

Results

Our results demonstrated that most of the 15 isolat

SUBMITTER: Bi Y 

PROVIDER: S-EPMC3236014 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature