The relationship of deiodinase 1 genotype and thyroid function to lifetime history of major depression in three independent populations.

ABSTRACT: Major depression (MD) is often associated with disturbances of the hypothalamic/pituitary/thyroid (HPT) axis. Unfortunately, whether this association is secondary to common underlying genetic variation or whether the MD-associated disturbances in HPT function are chronic or state-dependent is unknown. To examine these questions, we genotyped 12 single nucleotide polymorphisms identified in previous genome wide association analyses of thyroid function in DNA contributed by 1,555 subjects from three longitudinal ethnically diverse studies that are well-characterized for lifetime MD and thyroid function. We then examined associations between genetic variants and key outcomes of thyroid stimulating hormone, free thyroxine (FT4) and depression. We confirmed prior findings that two variants in d

SUBMITTER: Philibert RA 

PROVIDER: S-EPMC3236034 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature