Bioconcentration, metabolism and excretion of triclocarban in larval Qurt medaka (Oryzias latipes).

ABSTRACT: The antimicrobial triclocarban (TCC) is frequently found in personal care products and commonly observed in surface waters and sediments. Due to its long environmental persistence TCC accumulates in sewage sludge. It also shows a high unintended biological activity as a potent inhibitor of the soluble epoxide hydrolase (sEH) and may be an endocrine disruptor. In this study, we investigated bioconcentration, metabolism and elimination of TCC in fish using medaka (Oryzias latipes) as a model. Medaka larvae (7 ± 1 days post hatching) were exposed to 63 nM (20 μg/L) TCC water for 24h. The LC-MS/MS analysis of water and tissues provided bioconcentration of TCC and its metabolites in fish body and rapid excretion into culture water. Results from tissue samples showed a tissue concentration of 34

SUBMITTER: Schebb NH 

PROVIDER: S-EPMC3236035 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature