Transcriptome analysis of embryonic mammary cells reveals insights into mammary lineage establishment.

ABSTRACT:

Introduction

The mammary primordium forms during embryogenesis as a result of inductive interactions between its constitutive tissues, the mesenchyme and epithelium, and represents the earliest evidence of commitment to the mammary lineage. Previous studies of embryonic mouse mammary epithelium indicated that, by mid-gestation, these cells are determined to a mammary cell fate and that a stem cell population has been delimited. Mammary mesenchyme can induce mammary development from simple epithelium even across species and classes, and can partially restore features of differentiated tissue to mouse mammary tumours in co-culture experiments. Despite these exciting properties, the molecular identity of embryonic mammary cells remains to be fully characterised.

Methods

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SUBMITTER: Wansbury O 

PROVIDER: S-EPMC3236343 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature